Intrathecal activation of the IL-17/IL-8 axis in opticospinal multiple sclerosis

Intrathecal activation of the IL-17/IL-8 axis in opticospinal multiple sclerosis.

There are two distinct subtypes of multiple sclerosis in Asians, opticospinal (OS-multiple sclerosis) and conventional (C-multiple sclerosis). In OS-multiple sclerosis, selective and severe involvement of the optic nerves and spinal cord is characteristic, though its mechanisms are unknown. The present study aimed to find out possible differences in the cytokine/chemokine profiles in CSF betwee...

Hypothalamus syndrome in opticospinal multiple sclerosis.

This study describes a case of a patient with OSMS who presented with somnolence, periodic fever, memory impairment, and amenorrhea. Serum prolactin levels were found to be higher than normal. MR imaging showed a bilateral involvement of the hypothalamus. The clinical presentation, laboratory examination, and MR imaging findings suggested a diagnosis of hypothalamus syndrome in this patient.

Methylprednisolone treatment, immune activation, and intrathecal inflammation in multiple sclerosis.

A novel feature disclosed in opticospinal multiple sclerosis in Asians.

Increased evidence suggests that opticospinal multiple sclerosis (OS-MS) preferentially found in Asians is a distinct disease entity which differs from the conventional or universal form of MSin manyaspects. The following characteristics have been reported in OS-MS;1) severe and selective involvement of the optic nerve and spinal cord, 2) paucity of brain MRI lesions, 3) frequent occurrence of ...

Investigation of genetic variation of IL-4 receptor rs1801275 in patients with multiple sclerosis in Isfahan

Aim and Background: Multiple sclerosis (MS) is an autoimmune inflammatory disease that attacks myelinated axons in the central nervous system (CNS) resulting in destroying the myelin and the axon. According to high prevalence of disease in Iran, it needs to study different aspects of disease including factors influencing the pathogenesis and the other risk factors. Various type of genetic varia...